Heart disease is a major cause of death in the United States and cardiovascular disease (CVD) includes a wide range of complex conditions. Because the heart demands a large amount of energy, the heart is at risk for free radical damage that may be neutralized by antioxidants found in Proprietary Blend and HeartHealth. Many of the ingredients in Proprietary Blend along with the omega-3 fatty acids found in HeartHealth can also help reduce inflammation associated with heart disease. In fact, omega-3 fatty acids have been found effective against various cardiovascular issues including hypertension, arrhythmia and artherosclerosis.
- Many Americans have at least one form of heart disease
- Your heart works hard and beats at least 100,00 times per day
- The generation of energy by heart cells can cause free radical damage
- Antioxidants found in Olivamine® can neutralize free radicals
- Increased inflammation is a risk factor for heart disease
- Proprietary Blend and omega-3 fatty acids can reduce levels of inflammation
Heart disease is the number one cause of death in the United States. Approximately 1 in 4 Americans have or have had at least one form of cardiovascular disease (CVD) that includes hypertension, artheriosclerosis, stroke, myocardial infarction and heart failure. By 2030, it is estimated that 43.9% of the U.S. population will have CVD. CVD encompasses a large range of complex conditions including hypertension, atherosclerosis, and myocardial infarction1.
The heart is probably the hardest working organ in the human body. It’s composed mostly of muscle tissue and it works hard to pump oxygen-rich blood throughout the body. Amazingly, it beats approximately 100,000 times a day and consumes up to 30 kg of energy2. In response to the high energy demand in the heart, at least 25% of the human heart cell is composed of mitochondria, the subcellular powerhouses that produce most of the required energy in the form of the molecule, ATP3.
Free Radicals (ROS) Can Damage Heart Cells Leading to Heart Disease
The generation of ATP by mitochondria also results in potentially destructive free radical reactive oxygen species (ROS) as a byproduct. Free radicals are unstable because they contain unpaired electrons resulting in their capacity to steal electrons from other molecules in a process known as oxidation. Free radical damage can involve damage to cell membranes, DNA, proteins, lipids, and organelles including mitochondria. Oxidative stress results from the inability of cells to eliminate excessive ROS using natural antioxidant defense system that includes antioxidant defense enzymes4.
One antioxidant enzyme in particular, manganese superoxide dismutase (MnSOD), is critical for removal of ROS generated from mitochondria. In addition, mitochondria produce larger amounts of ROS when damaged or dysfunctional that can contribute substantially to oxidative stress5. Evidence suggests that oxidative stress is involved in the pathogenesis of a wide variety of cardiovascular diseases, including hypertension, atherosclerosis, and myocardial infarction6.
HeartHealth Includes Antioxidants that also Have Anti-inflammatory activity Along with Omega-3's
Proprietary Blend found in HeartHealth includes potent antioxidants such as the olive polyphenols, hydroxytyrosol and oleuropein, as well as taurine, N-acetylcysteine (NAC), methylsulfonylmethane (MSM) and vitamin B67-12. In addition, hydroxytyrosol, oleuropein and NAC activate the major antioxidant defense enzyme MnSOD13-15. All of these critical components of Proprietary Blendare anti-inflammatory and importantly, HeartHealth includes the omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that are also anti-inflammatory and have been found to favorably modify additional CVD risk factors including blood lipids, platelet aggregation and endothelial function16.
The omega-3 fatty acids found in HeartHealth are derived from fish oil that has been shown to have various cardiovascular benefits21. Importantly, marine-derived EPA and DHA have shared and complementary benefits and have been found effective against ischemic heart disease, atrial and ventricular arrhythmia, hypertension, peripheral artery disease, and heart failure17,18. In fact, DHA by itself has been shown to reduce atherosclerosis and hypertension by inhibiting the pro-inflammatory signaling molecule (IL-1 beta)19. In addition, large-scale clinical trials have shown that omega-3 fatty acids significantly decrease mortality associated with CVD17.
Only the highest quality ingredients are provided in Proprietary Blendhttp://www.olivamine.com and HeartHealth including from pure fish oil. Pinnaclife® HeartHealth with Proprietary Blend includes impeccably sourced ingredients that have undergone rigorous scientific review to prove that they renew, restore and repair cells.
- Circulation 2016; 133: e38-e60.
- Eur Heart J Suppl 2011; 13(Suppl C): C4-C13.
- Nat Rev Cardiol 2017; 14(4): 238-250.
- Curr Neuropharmacol 2009; 7: 65-74.
- Mitochondrion 2010; 10(4): 342-349.
- Clin Sci 2004; 106: 219-234.
- J Agric Food Chem 2011; 59: 4473-4482.
- Sci Pharm 2010; 78: 133-154.
- Amino Acids 2004; 26: 203-207.
- Nutrients 2017; 9(3): 290:1-21.
- Life Sci 2015; 121: 110-116.
- Front Genet 2018; 9: 388: 1-5.
- Age 2012; 34: 95-109.
- Cancer Res 2007; 67: 6392-6399.
- J Biol Regul Homeost Agents 2014; 28(1): 105-116.
- Food Funct 2018; 9: 3576-3596.
- Int J Mol Sci 2019; 20: 4025, 1-19.
- J Nutr 2012; 142: 14S-625S.
- J Am Heart Assoc 2018; 7: e008757, 1-14.