Vitamin C and Skin Health

Vitamin C is an essential nutrient for skin as well as the rest of the body.  It’s absolutely necessary for normal skin and bodily functions, cannot be naturally synthesized in humans and must be provided externally. Skin itself has various critical roles in overall health including protection from dehydration and infection, and its appearance is an important reflection on general well-being.

The epidermal layer of skin is responsible for most of its barrier function and includes many cells, particularly keratinocytes. In contrast, the lower dermal layer is composed mainly of fibroblasts that secrete the major component of the dermis, collagen fibers. In fact, collagen is the most abundant protein in the body and constitutes about 75% of skin.

Due to vitamin C’s substantial skin functions, it’s normally transported to the skin following consumption of a proper diet. However, vitamin C deficiency can result in scurvy characterized by weakened collagen structures, bruising, poor wound healing and impaired immunity.  Scientists believe this is due to the major role vitamin C plays as a co-factor for enzymes that stabilize the structure of collagen.

Notably, vitamin C (ascorbic acid) is water-soluble and susceptible to degradation by light and air.  An important stable form of vitamin C, ascorbyl-palmitate, is lipophilic (likes lipids), which allows it to associate with skin lipids and penetrate skin.  Following penetration, ascorbyl-palmitate is hydrolyzed in the skin to form ascorbic acid and palmitate. Evidence suggests that ascorbyl-palmitate, like other forms of vitamin C, has antioxidant and anti-inflammatory effects.

In addition to ascorbyl-palmitate, Viniferamine® skin and wound care products like Renewal Moisturizer contain other ingredients that are anti-inflammatory including the small molecule polyphenols oleuropein, resveratrol, and epigallocatechin-3-gallate (EGCG) from olives, grapes, and green tea, respectively, as well as the important small molecules, melatonin, and L-glutathione.  Moreover, dipotassium glycyrrhizate from licorice, avenanthramides in oats, aloe vera and shea butter possess anti-inflammatory activities. 

As mentioned, vitamin C helps stabilize collagen.  Vitamin C also promotes collagen synthesis and wound healing. Collagen is vital for its structural role in providing tensile strength to wounds.  In addition, collagen modulates critical inflammatory and wound healing processes by binding to receptors that activate other molecules involved in tissue remodeling and repair including metalloproteases (MMPs), cytokines and growth factor.

Improving collagen synthesis is especially important for people who frequently have impaired wound healing including individuals with diabetes, cancer or advanced age. In addition, Viniferamine® skin and wound care products contain other ingredients along with ascorbyl-palmitate that promote collagen synthesis including titrated extract of Centella asiatica (TECA) and aloe vera that also enhance wound healing.

Furthermore, studies indicate that vitamin C increases the proliferation and migration of dermal fibroblasts essential for tissue remodeling and wound healing.  In the initial stages of wound healing, neutrophils migrate to the wound site to kill invading microbes. Evidence suggests that vitamin C enhances immune responses including neutrophil microbial killing and clearance by macrophages. In addition, studies have shown that vitamin C promotes the production of barrier lipids and the maturation of keratinocytes suggesting that vitamin C plays a major role in the formation of the skin barrier and protection against water loss. 

Oxidative stress that typically leads to inflammation, results from the inability of cells to eliminate free radicals known as reactive oxygen species (ROS) using the natural defense system that includes defense enzymes such as superoxide dismutase (SOD).  Vitamin C is a potent antioxidant that can neutralize and remove free radical oxidants including those due to pollution or ultraviolet radiation (UV).  Vitamin C also regenerates Vitamin E helping limit oxidative damage to cell membranes.

In fact, Viniferamine® skin and wound care products like Silicone Barrier contain many antioxidant ingredients including oleuropein, resveratrol, and EGCG, as well as melatonin, and L-glutathione.  Notably, in a model where MnSOD was deactivated, oleuropein induced MnSOD activity; EGCG has been found to induce MnSOD expression, and resveratrol has been shown to upregulate MnSOD activity.

It’s good to know that Viniferamine® skin and wound care products include ingredients like vitamin C (ascorbyl-palmitate) that are anti-inflammatory, have potent antioxidant activity and that stimulate wound healing. Vitamin C also helps protect against oxidative stress, helps strengthen the skin barrier, and enhances skin immune cell resScars are areas in the skin where fibrosis has replaced normal tissue during wound healing following injury.


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About the author: Nancy Ray, PhD is the Vice President of Scientific Affairs at McCord Research. Dr. Ray received her PhD in Biochemistry and Biophysics and was a postdoctoral fellow at NIH, Harvard University and Dana-Farber Cancer Institute, and the University of Iowa. She also earned bachelor of science degrees in Chemistry and Microbiology.

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